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TargetE3 SUMO-protein ligase CBX4
LigandBDBM50194252
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1616630
IC50>60000±n/a nM
Citation Stuckey JISimpson CNorris-Drouin JLCholensky SHLee JPasca RCheng NDickson BMPearce KHFrye SVJames LI Structure-Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains. J Med Chem 59:8913-8923 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
E3 SUMO-protein ligase CBX4
Name:E3 SUMO-protein ligase CBX4
Synonyms:6.3.2.- | CBX4 | Chromobox protein homolog 4 | Pc2 | Polycomb 2 homolog | hPc2
Type:PROTEIN
Mol. Mass.:61401.05
Organism:Homo sapiens (Human)
Description:ChEMBL_108273
Residue:560
Sequence:
MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNR
ERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTDNRAKLDLGAQGKGQGHQY
ELNSKKHHQYQPHSKERAGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEA
PSPTCPDLGAKSHPPDKWAQGAGAKGYLGAVKPLAGAAGAPGKGSEKGPPNGMMPAPKEA
VTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEVAEGEARSPSHKKRAAD
ERHPPADRTFKKAAGAEEKKVEAPPKRREEEVSGVSDPQPQDAGSRKLSPTKEAFGEQPL
QLTTKPDLLAWDPARNTHPPSHHPHPHPHHHHHHHHHHHHAVGLNLSHVRKRCLSETHGE
REPCKKRLTARSISTPTCLGGSPAAERPADLPPAAALPQPEVILLDSDLDEPIDLRCVKT
RSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNI
IITDVTANCLTVTFKEYVTV
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BDBM50194252
n/a
NameBDBM50194252
Synonyms:CHEMBL3922982
TypeSmall organic molecule
Emp. Form.C46H65N7O10
Mol. Mass.876.0492
SMILESCOC(=O)[C@H](CO)NC(=O)[C@H](CCCCN(C1CC2CCC1C2)C(C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)c1ccccc1 |r|
Structure
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