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TargetTyrosine-protein kinase BTK
LigandBDBM230081
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1616836 (CHEMBL3858905)
IC50 1.000000±n/a nM
Citation Watterson, SHDe Lucca, GVShi, QLangevine, CMLiu, QBatt, DGBeaudoin Bertrand, MGong, HDai, JYip, SLi, PSun, DWu, DRWang, CZhang, YTraeger, SCPattoli, MASkala, SCheng, LObermeier, MTVickery, RDiscenza, LND'Arienzo, CJZhang, YHeimrich, EGillooly, KMTaylor, TLPulicicchio, CMcIntyre, KWGalella, MATebben, AJMuckelbauer, JKChang, CRampulla, RMathur, ASalter-Cid, LBarrish, JCCarter, PHFura, ABurke, JRTino, JA Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locke J Med Chem59:9173-9200 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase BTK
Name:Tyrosine-protein kinase BTK
Synonyms:AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:Enzyme
Mol. Mass.:76289.95
Organism:Homo sapiens (Human)
Description:Q06187
Residue:659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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  Blast E-value cutoff:
BDBM230081
n/a
NameBDBM230081
Synonyms:US9334290, 1 | US9334290, 2
TypeSmall organic molecule
Emp. Form.C32H26ClFN4O4
Mol. Mass.585.025
SMILESCc1c(cccc1-n1c(=O)n(C)c2c(F)cccc2c1=O)-c1c(Cl)cc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O |(2.75,9.19,;1.42,8.42,;.08,9.19,;-1.25,8.42,;-1.25,6.88,;.08,6.11,;1.42,6.88,;2.75,6.11,;2.75,4.57,;1.42,3.8,;4.09,3.8,;4.09,2.26,;5.42,4.57,;6.75,3.8,;6.75,2.26,;8.09,4.57,;8.09,6.11,;6.75,6.88,;5.42,6.11,;4.09,6.88,;4.09,8.42,;.08,10.73,;1.42,11.5,;2.96,11.5,;1.42,13.04,;.08,13.81,;.08,15.35,;1.42,16.12,;-1.25,16.12,;-1.25,13.04,;-2.71,13.51,;-3.62,12.27,;-5.15,12.1,;-5.78,10.7,;-4.87,9.45,;-3.34,9.61,;-2.71,11.02,;-1.25,11.5,;-7.32,10.7,;-8.09,9.36,;-6.55,9.36,;-8.09,12.03,)|
Structure
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