| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 1 [11-371] |
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| Ligand | BDBM178103 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1616968 (CHEMBL3859037) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Shen, Y; Szewczyk, MM; Eram, MS; Smil, D; Kaniskan, HÜ; de Freitas, RF; Senisterra, G; Li, F; Schapira, M; Brown, PJ; Arrowsmith, CH; Barsyte-Lovejoy, D; Liu, J; Vedadi, M; Jin, J Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem59:9124-9139 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 1 [11-371] |
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| Name: | Protein arginine N-methyltransferase 1 [11-371] |
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| Synonyms: | ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1 |
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| Type: | Protein |
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| Mol. Mass.: | 41506.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99873[11-371] |
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| Residue: | 361 |
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| Sequence: | MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDE
VRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIV
KANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGL
IFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNAC
LIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYT
HWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRM
R
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| BDBM178103 |
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| n/a |
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| Name | BDBM178103 |
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| Synonyms: | MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1H-pyrrol-3-yl)methyl)-N1-methylethane-1,2-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C17H25N3O |
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| Mol. Mass. | 287.3999 |
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| SMILES | CC(C)Oc1ccc(cc1)-c1c[nH]cc1CN(C)CCN |
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| Structure | 
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