| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone-arginine methyltransferase CARM1 |
|---|
| Ligand | BDBM50194789 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1616973 (CHEMBL3859042) |
|---|
| IC50 | 85±n/a nM |
|---|
| Citation |  Shen, Y; Szewczyk, MM; Eram, MS; Smil, D; Kaniskan, HÜ; de Freitas, RF; Senisterra, G; Li, F; Schapira, M; Brown, PJ; Arrowsmith, CH; Barsyte-Lovejoy, D; Liu, J; Vedadi, M; Jin, J Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem59:9124-9139 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone-arginine methyltransferase CARM1 |
|---|
| Name: | Histone-arginine methyltransferase CARM1 |
|---|
| Synonyms: | CARM1 | CARM1_HUMAN | Coactivator-associated arginine methyltransferase 1 | Coactivator-associated arginine methyltransferase 1 (CARM1) | PRMT4 | Protein arginine N-methyltransferase 4 | Protein arginine methyltransferase 4 (PRMT4) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 65855.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q86X55 |
|---|
| Residue: | 608 |
|---|
| Sequence: | MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEV
RAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSF
YNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPG
KVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDE
QLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFL
EAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRC
LFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTT
PSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSSVGHNNLIPLAN
TGIVNHTHSRMGSIMSTGIVQGSSGAQGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIP
TNTMHYGS
|
|
|
|---|
| BDBM50194789 |
|---|
| n/a |
|---|
| Name | BDBM50194789 |
|---|
| Synonyms: | CHEMBL3902609 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H32N2O |
|---|
| Mol. Mass. | 304.4702 |
|---|
| SMILES | CNCCN1CCC(CC1)OCc1ccc(CC(C)C)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
