| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 4 |
|---|
| Ligand | BDBM50195059 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1617390 (CHEMBL3859459) |
|---|
| IC50 | 11±n/a nM |
|---|
| Citation |  Tsuno, N; Yukimasa, A; Yoshida, O; Ichihashi, Y; Inoue, T; Ueno, T; Yamaguchi, H; Matsuda, H; Funaki, S; Yamanada, N; Tanimura, M; Nagamatsu, D; Nishimura, Y; Ito, T; Soga, M; Horita, N; Yamamoto, M; Hinata, M; Imai, M; Morioka, Y; Kanemasa, T; Sakaguchi, G; Iso, Y Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1. Bioorg Med Chem Lett26:4930-4935 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential cation channel subfamily V member 4 |
|---|
| Name: | Transient receptor potential cation channel subfamily V member 4 |
|---|
| Synonyms: | TRPV4 | TRPV4_HUMAN | Transient receptor potential cation channel subfamily V member 4 (TRPV4) | VRL2 | VROAC |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 98290.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9HBA0 |
|---|
| Residue: | 871 |
|---|
| Sequence: | MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP
GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN
KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL
TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT
ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI
VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS
NLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYD
LSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLC
AMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGV
NSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTG
TYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSC
RDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGE
TVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV
DEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDE
VVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL
|
|
|
|---|
| BDBM50195059 |
|---|
| n/a |
|---|
| Name | BDBM50195059 |
|---|
| Synonyms: | CHEMBL3932523 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H16N4O2S2 |
|---|
| Mol. Mass. | 360.454 |
|---|
| SMILES | CCOC(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1 |
|---|
| Structure | 
|
|---|
Search and Browse
