| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50195224 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1617511 (CHEMBL3859580) |
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| IC50 | 0.580000±n/a nM |
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| Citation |  Imaeda, Y; Tawada, M; Suzuki, S; Tomimoto, M; Kondo, M; Tarui, N; Sanada, T; Kanagawa, R; Snell, G; Behnke, CA; Kubo, K; Kuroita, T Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors. Bioorg Med Chem24:5771-5780 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50195224 |
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| n/a |
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| Name | BDBM50195224 |
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| Synonyms: | CHEMBL3916240 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H37Cl2N5O2 |
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| Mol. Mass. | 486.478 |
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| SMILES | Cl.Cl.CC(C)CN([C@H]1CCCNC1)C(=O)c1cnc(nc1NCc1ccco1)C(C)(C)C |r| |
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| Structure | 
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