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TargetDipeptidyl peptidase 1
LigandBDBM50195242
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1617560 (CHEMBL3859629)
IC50 16±n/a nM
Citation Connolly, SLönn, HKäck, HVan de Poël, ADahl, GDoyle, KGardiner, PRoot, JWikell, CJohannesson, PStenvall, KSwallow, S Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986). J Med Chem59:9457-9472 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dipeptidyl peptidase 1
Name:Dipeptidyl peptidase 1
Synonyms:CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI)
Type:Enzyme
Mol. Mass.:51857.28
Organism:Homo sapiens (Human)
Description:P53634
Residue:463
Sequence:
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50195242
n/a
NameBDBM50195242
Synonyms:CHEMBL3917575 | US10287258, Example 14 | US10669245, Example 14 | US11117874, Example 14 | US11655221, Example 14 | US11680049, Example 14 | US20230278969, Example 14
TypeSmall organic molecule
Emp. Form.C24H24F2N4O3
Mol. Mass.454.4692
SMILESCN1C(=O)C(F)(F)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r|
Structure
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