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TargetDipeptidyl peptidase I
LigandBDBM50195235
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1617600
IC50 115±n/a nM
Citation Connolly SLönn HKäck HVan de Poël ADahl GDoyle KGardiner PRoot JWikell CJohannesson PStenvall KSwallow S Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986). J Med Chem 59:9457-9472 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dipeptidyl peptidase I
Name:Dipeptidyl peptidase I
Synonyms:Cathepsin C | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I (DPPI)
Type:Enzyme
Mol. Mass.:51857.28
Organism:Homo sapiens (Human)
Description:P53634
Residue:463
Sequence:
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50195235
n/a
NameBDBM50195235
Synonyms:CHEMBL3900409
TypeSmall organic molecule
Emp. Form.C23H24N4O4
Mol. Mass.420.4611
SMILESCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r|
Structure
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