| Reaction Details |
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 | Report a problem with these data |
| Target | Pro-cathepsin H |
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| Ligand | BDBM50195235 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1617591 (CHEMBL3859660) |
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| IC50 | >20000±n/a nM |
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| Citation |  Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986). J Med Chem59:9457-9472 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pro-cathepsin H |
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| Name: | Pro-cathepsin H |
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| Synonyms: | CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37402.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1459870 |
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| Residue: | 335 |
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| Sequence: | MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS
NWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSV
DWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHG
CQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMV
EAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVK
NSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
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| BDBM50195235 |
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| n/a |
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| Name | BDBM50195235 |
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| Synonyms: | CHEMBL3900409 | US10287258, Example 2 | US10669245, Example 2 | US11117874, Example 2 | US11655221, Example 2 | US11680049, Example 2 | US20230278969, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N4O4 |
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| Mol. Mass. | 420.4611 |
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| SMILES | Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| |
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| Structure | 
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