| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dipeptidyl peptidase 1 |
|---|
| Ligand | BDBM50195249 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1617559 (CHEMBL3859628) |
|---|
| IC50 | 40±n/a nM |
|---|
| Citation |  Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986). J Med Chem59:9457-9472 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dipeptidyl peptidase 1 |
|---|
| Name: | Dipeptidyl peptidase 1 |
|---|
| Synonyms: | CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51857.28 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P53634 |
|---|
| Residue: | 463 |
|---|
| Sequence: | MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
|
|
|
|---|
| BDBM50195249 |
|---|
| n/a |
|---|
| Name | BDBM50195249 |
|---|
| Synonyms: | CHEMBL3970692 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H26N4O |
|---|
| Mol. Mass. | 386.4894 |
|---|
| SMILES | N[C@H]1CCCCC[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
