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TargetDipeptidyl peptidase 1
LigandBDBM50195262
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1617559 (CHEMBL3859628)
IC50 63±n/a nM
Citation Connolly, SLönn, HKäck, HVan de Poël, ADahl, GDoyle, KGardiner, PRoot, JWikell, CJohannesson, PStenvall, KSwallow, S Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986). J Med Chem59:9457-9472 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dipeptidyl peptidase 1
Name:Dipeptidyl peptidase 1
Synonyms:CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI)
Type:Enzyme
Mol. Mass.:51857.28
Organism:Homo sapiens (Human)
Description:P53634
Residue:463
Sequence:
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50195262
n/a
NameBDBM50195262
Synonyms:CHEMBL3966946 | US11655221, Example 34 | US20230278969, Example 34
TypeSmall organic molecule
Emp. Form.C22H22N4O2
Mol. Mass.374.4357
SMILESO=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)C1CNCCCO1 |r|
Structure
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