| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysophosphatidic acid receptor 1 |
|---|
| Ligand | BDBM50195700 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1617900 (CHEMBL3859969) |
|---|
| IC50 | 3.5±n/a nM |
|---|
| Citation |  Terakado, M; Suzuki, H; Hashimura, K; Tanaka, M; Ueda, H; Kohno, H; Fujimoto, T; Saga, H; Nakade, S; Habashita, H; Takaoka, Y; Seko, T Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead. ACS Med Chem Lett7:913-918 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysophosphatidic acid receptor 1 |
|---|
| Name: | Lysophosphatidic acid receptor 1 |
|---|
| Synonyms: | EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41120.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q92633 |
|---|
| Residue: | 364 |
|---|
| Sequence: | MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVC
IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST
WLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS
RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA
EFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND
HSVV
|
|
|
|---|
| BDBM50195700 |
|---|
| n/a |
|---|
| Name | BDBM50195700 |
|---|
| Synonyms: | CHEMBL3975893 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H32ClNO6 |
|---|
| Mol. Mass. | 574.063 |
|---|
| SMILES | COc1cc(cc(OC)c1C)C(=O)N(CCCc1ccccc1)Cc1ccc(Oc2ccc(Cl)cc2C(O)=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
