Citation | Lelais, G; Epple, R; Marsilje, TH; Long, YO; McNeill, M; Chen, B; Lu, W; Anumolu, J; Badiger, S; Bursulaya, B; DiDonato, M; Fong, R; Juarez, J; Li, J; Manuia, M; Mason, DE; Gordon, P; Groessl, T; Johnson, K; Jia, Y; Kasibhatla, S; Li, C; Isbell, J; Spraggon, G; Bender, S; Michellys, PY Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Ce J Med Chem59:6671-89 (2016) [PubMed] Article |
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SMILES | Cc1cccc2nc(NC(=O)c3cccc(c3)C(F)(F)F)n([C@H]3CC[C@H](O)CC3)c12 |r,wU:22.22,wD:25.26,(26.54,-21.82,;26.54,-20.28,;25.2,-19.51,;25.2,-17.97,;26.53,-17.2,;27.87,-17.96,;29.34,-17.48,;30.26,-18.73,;31.8,-18.73,;32.57,-17.4,;31.79,-16.07,;34.1,-17.4,;34.87,-16.07,;36.4,-16.06,;37.18,-17.4,;36.41,-18.74,;34.87,-18.74,;37.18,-20.07,;36.41,-21.4,;38.72,-20.07,;37.94,-21.4,;29.34,-19.99,;29.83,-21.46,;31.33,-21.77,;31.8,-23.24,;30.77,-24.39,;31.24,-25.85,;29.26,-24.06,;28.79,-22.6,;27.87,-19.51,)| |