| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 4 |
|---|
| Ligand | BDBM50196276 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1618265 (CHEMBL3860434) |
|---|
| EC50 | 15±n/a nM |
|---|
| Citation |  Mona, CE; Besserer-Offroy, É; Cabana, J; Lefrançois, M; Boulais, PE; Lefebvre, MR; Leduc, R; Lavigne, P; Heveker, N; Marsault, É; Escher, E Structure-Activity Relationship and Signaling of New Chimeric CXCR4 Agonists. J Med Chem59:7512-24 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-X-C chemokine receptor type 4 |
|---|
| Name: | C-X-C chemokine receptor type 4 |
|---|
| Synonyms: | C-X-C chemokine receptor type 4 | C-X-C chemokine receptor type 4 (CXCR4) | CD_antigen=CD184 | CXC-R4 | CXCR-4 | CXCR4 | CXCR4_HUMAN | FB22 | Fusin | HM89 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 39754.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P61073 |
|---|
| Residue: | 352 |
|---|
| Sequence: | MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
|
|
|
|---|
| BDBM50196276 |
|---|
| n/a |
|---|
| Name | BDBM50196276 |
|---|
| Synonyms: | CHEMBL3982241 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C140H224N46O31S2 |
|---|
| Mol. Mass. | 3111.696 |
|---|
| SMILES | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
