| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity choline transporter 1 |
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| Ligand | BDBM50196416 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1618520 (CHEMBL3860689) |
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| IC50 | 467±n/a nM |
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| Citation |  Bertron, JL; Ennis, EA; Tarr, CJ; Wright, J; Dickerson, JW; Locuson, CW; Blobaum, AL; Rook, JM; Blakely, RD; Lindsley, CW Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound. Bioorg Med Chem Lett26:4637-4640 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity choline transporter 1 |
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| Name: | High affinity choline transporter 1 |
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| Synonyms: | CHT1 | High-affinity choline transporter | SC5A7_HUMAN | SLC5A7 | high affinity choline transporter 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63194.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1464247 |
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| Residue: | 580 |
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| Sequence: | MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTA
TWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQ
IYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGG
LYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSW
LDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDW
NQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFA
RNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQ
LLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFK
TLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLD
ELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ
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| BDBM50196416 |
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| n/a |
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| Name | BDBM50196416 |
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| Synonyms: | CHEMBL3899143 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26FN3O3 |
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| Mol. Mass. | 375.4371 |
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| SMILES | CC(C)c1cc(CNC(=O)c2ccc(F)c(OC3CCN(C)CC3)c2)on1 |
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| Structure | 
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