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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cGMP-specific 3',5'-cyclic phosphodiesterase | ||
| Ligand | BDBM50196779 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1618821 (CHEMBL3860990) | ||
| IC50 | 38±n/a nM | ||
| Citation |  Rabal, O; Sánchez-Arias, JA; Cuadrado-Tejedor, M; de Miguel, I; Pérez-González, M; García-Barroso, C; Ugarte, A; Estella-Hermoso de Mendoza, A; Sáez, E; Espelosin, M; Ursua, S; Haizhong, T; Wei, W; Musheng, X; Garcia-Osta, A; Oyarzabal, J Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease. J Med Chem59:8967-9004 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cGMP-specific 3',5'-cyclic phosphodiesterase | |||
| Name: | cGMP-specific 3',5'-cyclic phosphodiesterase | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | CGB-PDE | PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase 2 and 5 (PDE2 and PDE5) | Phosphodiesterase 5 (PDE5) | Phosphodiesterase 5A | Phosphodiesterase 5A (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3',5'-cyclic phosphodiesterase | ||
| Type: | Protein | ||
| Mol. Mass.: | 99975.83 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O76074 | ||
| Residue: | 875 | ||
| Sequence: |
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| BDBM50196779 | |||
| n/a | |||
| Name | BDBM50196779 | ||
| Synonyms: | CHEMBL3976546 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H33N5O4 | ||
| Mol. Mass. | 467.5606 | ||
| SMILES | CCOc1ccc(CC2CCC(CC(=O)NO)CC2)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 |(50.87,-36.7,;50.87,-38.24,;52.21,-39.01,;52.21,-40.55,;50.88,-41.32,;50.88,-42.86,;52.22,-43.63,;52.23,-45.17,;53.57,-45.93,;53.56,-47.47,;54.89,-48.23,;56.23,-47.46,;57.56,-48.23,;58.89,-47.46,;58.89,-45.92,;60.22,-48.23,;61.56,-47.46,;56.22,-45.92,;54.89,-45.15,;53.55,-42.85,;53.54,-41.32,;54.87,-40.55,;56.2,-41.31,;57.53,-40.54,;58.99,-41.01,;59.47,-42.48,;60.97,-42.8,;59.89,-39.77,;58.99,-38.53,;59.47,-37.07,;57.53,-39.01,;56.2,-38.23,;56.2,-36.69,;54.87,-39.01,)| | ||
| Structure | 
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