| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 1 |
|---|
| Ligand | BDBM50380399 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1619173 |
|---|
| IC50 | 1110±n/a nM |
|---|
| Citation |  Zwick V; Simões-Pires CA; Nurisso A; Petit C; Dos Santos Passos C; Randazzo GM; Martinet N; Bertrand P; Cuendet M Synthesis of a selective HDAC6 inhibitor active in neuroblasts. Bioorg Med Chem Lett 26:4955-4959 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 1 |
|---|
| Name: | Histone deacetylase 1/6 |
|---|
| Synonyms: | HD1 | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55090.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Purified from NIH 3T3 cells harboring human HDAC1 using an anti-FLAG M2 antibody. |
|---|
| Residue: | 482 |
|---|
| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
|
|
|
|---|
| BDBM50380399 |
|---|
| n/a |
|---|
| Name | BDBM50380399 |
|---|
| Synonyms: | CHEMBL2018302 | Tubastatin A | US8748451, 6 | US9249087, Tubacin | US9751832, Tubastatin A |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21N3O2 |
|---|
| Mol. Mass. | 335.3996 |
|---|
| SMILES | CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO |
|---|
| Structure | 
|
|---|
Search and Browse
