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TargetHigh affinity nerve growth factor receptor
LigandBDBM50111443
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1619559 (CHEMBL3861728)
IC50 5880±n/a nM
Citation Norman, BHMcDermott, JS Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain. J Med Chem60:66-88 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
High affinity nerve growth factor receptor
Name:High affinity nerve growth factor receptor
Synonyms:High affinity nerve growth factor receptor | NTRK1_RAT | Neurotrophic tyrosine kinase receptor type 1 | Ntrk1 | Slow nerve growth factor receptor | Trk | Trk-A | Trka | p140-TrkA
Type:PROTEIN
Mol. Mass.:87865.88
Organism:Rattus norvegicus
Description:ChEMBL_100078
Residue:799
Sequence:
MLRGQRHGQLGWHRPAAGLGGLVTSLMLACACAASCRETCCPVGPSGLRCTRAGTLNTLR
GLRGAGNLTELYVENQRDLQRLEFEDLQGLGELRSLTIVKSGLRFVAPDAFHFTPRLSHL
NLSSNALESLSWKTVQGLSLQDLTLSGNPLHCSCALLWLQRWEQEDLCGVYTQKLQGSGS
GDQFLPLGHNNSCGVPSVKIQMPNDSVEVGDDVFLQCQVEGQALQQADWILTELEGTATM
KKSGDLPSLGLTLVNVTSDLNKKNVTCWAENDVGRAEVSVQVSVSFPASVHLGKAVEQHH
WCIPFSVDGQPAPSLRWFFNGSVLNETSFIFTQFLESALTNETMRHGCLRLNQPTHVNNG
NYTLLAANPYGQAAASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSRDPVEKKDETPFG
VSVAVGLAVSAALFLSALLLVLNKCGQRSKFGINRPAVLAPEDGLAMSLHFMTLGGSSLS
PTEGKGSGLQGHIMENPQYFSDTCVHHIKRQDIILKWELGEGAFGKVFLAECYNLLNDQD
KMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDL
NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCL
VGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVL
WEIFTYGKQPWYQLSNTEAIECITQGRELERPRACPPDVYAIMRGCWQREPQQRLSMKDV
HARLQALAQAPPSYLDVLG
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  Blast E-value cutoff:
BDBM50111443
n/a
NameBDBM50111443
Synonyms:2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquinoline-1,3-dione(ALE-0540) | CHEMBL440470
TypeSmall organic molecule
Emp. Form.C14H11N3O5
Mol. Mass.301.2542
SMILESOCCNN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O
Structure
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