| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet-activating factor acetylhydrolase |
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| Ligand | BDBM50197661 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1619620 (CHEMBL3861789) |
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| IC50 | 1000±n/a nM |
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| Citation |  Woolford, AJ; Day, PJ; Bénéton, V; Berdini, V; Coyle, JE; Dudit, Y; Grondin, P; Huet, P; Lee, LY; Manas, ES; McMenamin, RL; Murray, CW; Page, LW; Patel, VK; Potvain, F; Rich, SJ; Sang, Y; Somers, DO; Trottet, L; Wan, Z; Zhang, X Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA J Med Chem59:10738-10749 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet-activating factor acetylhydrolase |
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| Name: | Platelet-activating factor acetylhydrolase |
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| Synonyms: | 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50084.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_156212 |
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| Residue: | 441 |
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| Sequence: | MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
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| BDBM50197661 |
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| n/a |
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| Name | BDBM50197661 |
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| Synonyms: | CHEMBL3924430 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19FN2O2 |
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| Mol. Mass. | 338.3755 |
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| SMILES | C[C@]1(CN(CCOc2ccc(F)c(c2)C#N)C(=O)C1)c1ccccc1 |r| |
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| Structure | 
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