Reaction Details |
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Target | Platelet-activating factor acetylhydrolase |
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Ligand | BDBM50197672 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1619621 (CHEMBL3861790) |
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IC50 | 2700±n/a nM |
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Citation | Woolford, AJ; Day, PJ; Bénéton, V; Berdini, V; Coyle, JE; Dudit, Y; Grondin, P; Huet, P; Lee, LY; Manas, ES; McMenamin, RL; Murray, CW; Page, LW; Patel, VK; Potvain, F; Rich, SJ; Sang, Y; Somers, DO; Trottet, L; Wan, Z; Zhang, X Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA J Med Chem59:10738-10749 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Platelet-activating factor acetylhydrolase |
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Name: | Platelet-activating factor acetylhydrolase |
Synonyms: | 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase |
Type: | PROTEIN |
Mol. Mass.: | 50084.41 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_156212 |
Residue: | 441 |
Sequence: | MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
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BDBM50197672 |
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n/a |
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Name | BDBM50197672 |
Synonyms: | CHEMBL3956821 |
Type | Small organic molecule |
Emp. Form. | C20H26FN3O2 |
Mol. Mass. | 359.4377 |
SMILES | CN1CCC(C)(CC1)[C@@H]1CN(CCOc2ccc(F)c(c2)C#N)C(=O)C1 |r| |
Structure |
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