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TargetPlatelet-activating factor acetylhydrolase
LigandBDBM50197674
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1619621 (CHEMBL3861790)
IC50 620±n/a nM
Citation Woolford, AJDay, PJBénéton, VBerdini, VCoyle, JEDudit, YGrondin, PHuet, PLee, LYManas, ESMcMenamin, RLMurray, CWPage, LWPatel, VKPotvain, FRich, SJSang, YSomers, DOTrottet, LWan, ZZhang, X Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA J Med Chem59:10738-10749 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Platelet-activating factor acetylhydrolase
Name:Platelet-activating factor acetylhydrolase
Synonyms:1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase
Type:PROTEIN
Mol. Mass.:50084.41
Organism:Homo sapiens (Human)
Description:ChEMBL_156212
Residue:441
Sequence:
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50197674
n/a
NameBDBM50197674
Synonyms:CHEMBL3933361
TypeSmall organic molecule
Emp. Form.C20H26FN3O4
Mol. Mass.391.4365
SMILESOC=O.CC1(CCNCC1)C1CN(CCOc2ccc(F)c(c2)C#N)C(=O)C1
Structure
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