Reaction Details |
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Target | NAD-dependent protein deacetylase sirtuin-2 |
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Ligand | BDBM50197682 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1619693 (CHEMBL3861862) |
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IC50 | 8200±n/a nM |
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Citation | Seifert, T; Malo, M; Lengqvist, J; Sihlbom, C; Jarho, EM; Luthman, K Identification of the Binding Site of Chroman-4-one-Based Sirtuin 2-Selective Inhibitors using Photoaffinity Labeling in Combination with Tandem Mass Spectrometry. J Med Chem59:10794-10799 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NAD-dependent protein deacetylase sirtuin-2 |
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Name: | NAD-dependent protein deacetylase sirtuin-2 |
Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
Type: | Hydrolase |
Mol. Mass.: | 43172.62 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 389 |
Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
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BDBM50197682 |
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n/a |
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Name | BDBM50197682 |
Synonyms: | CHEMBL3944975 |
Type | Small organic molecule |
Emp. Form. | C16H17F3N2O2 |
Mol. Mass. | 326.3136 |
SMILES | CCCCCC1CC(=O)c2cc(ccc2O1)C1(N=N1)C(F)(F)F |c:19| |
Structure |
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