Reaction Details |
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Target | 17-beta-hydroxysteroid dehydrogenase type 2 |
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Ligand | BDBM50360232 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1619745 (CHEMBL3861914) |
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IC50 | 100±n/a nM |
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Citation | Braun, F; Bertoletti, N; Möller, G; Adamski, J; Steinmetzer, T; Salah, M; Abdelsamie, AS; van Koppen, CJ; Heine, A; Klebe, G; Marchais-Oberwinkler, S First Structure-Activity Relationship of 17ß-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme. J Med Chem59:10719-10737 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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17-beta-hydroxysteroid dehydrogenase type 2 |
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Name: | 17-beta-hydroxysteroid dehydrogenase type 2 |
Synonyms: | 17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase |
Type: | Oxidoreductase; single-pass type II membrane protein |
Mol. Mass.: | 42795.29 |
Organism: | Homo sapiens (Human) |
Description: | Enzyme was partially purified from human placenta. |
Residue: | 387 |
Sequence: | MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
YFAKRHFGQDKPMPRALRMPNYKKKAT
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BDBM50360232 |
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n/a |
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Name | BDBM50360232 |
Synonyms: | CHEMBL1928186 |
Type | Small organic molecule |
Emp. Form. | C19H14FNO3 |
Mol. Mass. | 323.3178 |
SMILES | Cc1cc(ccc1O)-c1ccc(nc1)C(=O)c1ccc(F)c(O)c1 |
Structure |
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