| Reaction Details |
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 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 1 |
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| Ligand | BDBM50360234 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1619744 (CHEMBL3861913) |
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| IC50 | 19650±n/a nM |
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| Citation |  Braun, F; Bertoletti, N; Möller, G; Adamski, J; Steinmetzer, T; Salah, M; Abdelsamie, AS; van Koppen, CJ; Heine, A; Klebe, G; Marchais-Oberwinkler, S First Structure-Activity Relationship of 17ß-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme. J Med Chem59:10719-10737 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 17-beta-hydroxysteroid dehydrogenase type 1 |
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| Name: | 17-beta-hydroxysteroid dehydrogenase type 1 |
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| Synonyms: | 17-beta-HSD 1 | 17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1) | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB1_HUMAN | E17KSR | E2DH | EDH17B1 | EDH17B2 | EDHB17 | Estradiol 17-beta-dehydrogenase 1 | Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1) | HSD17B1 | Placental 17-beta-hydroxysteroid dehydrogenase | SDR28C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 34945.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14061 |
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| Residue: | 328 |
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| Sequence: | MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRGAVGDPELGDPPAAPQ
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| BDBM50360234 |
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| n/a |
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| Name | BDBM50360234 |
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| Synonyms: | CHEMBL1928188 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15NO3 |
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| Mol. Mass. | 305.3273 |
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| SMILES | Cc1cc(ccc1O)-c1cccc(n1)C(=O)c1cccc(O)c1 |
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| Structure | 
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