| Reaction Details |
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 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase 14 |
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| Ligand | BDBM50197863 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1619749 (CHEMBL3861918) |
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| Ki | 86±n/a nM |
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| Citation |  Braun, F; Bertoletti, N; Möller, G; Adamski, J; Steinmetzer, T; Salah, M; Abdelsamie, AS; van Koppen, CJ; Heine, A; Klebe, G; Marchais-Oberwinkler, S First Structure-Activity Relationship of 17ß-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme. J Med Chem59:10719-10737 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 17-beta-hydroxysteroid dehydrogenase 14 |
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| Name: | 17-beta-hydroxysteroid dehydrogenase 14 |
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| Synonyms: | 17-beta-HSD 14 | 17-beta-hydroxysteroid dehydrogenase 14 | 17-beta-hydroxysteroid dehydrogenase DHRS10 | DHB14_HUMAN | DHRS10 | DHRS10 | Dehydrogenase/reductase SDR family member 10 | HSD17B14 | Retinal short-chain dehydrogenase/reductase retSDR3 | SDR3 | SDR47C1 | Short chain dehydrogenase/reductase family 47C member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28316.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_114829 |
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| Residue: | 270 |
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| Sequence: | MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFIL
CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT
LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN
CISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTG
IELLVTGGAELGYGCKASRSTPVDAPDIPS
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| BDBM50197863 |
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| n/a |
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| Name | BDBM50197863 |
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| Synonyms: | CHEMBL3968387 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H13F2NO4 |
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| Mol. Mass. | 357.3076 |
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| SMILES | OCc1cc(nc(c1)-c1cccc(O)c1F)C(=O)c1ccc(F)c(O)c1 |
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| Structure | 
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