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TargetCathepsin B
LigandBDBM50197886
Substrate/Competitorn/a
Meas. Tech.ChEBML_1620100
IC50 57±n/a nM
Citation Plebanek, EChevrier, FRoy, VGarenne, TLecaille, FWarszycki, DBojarski, AJLalmanach, GAgrofoglio, LA Straightforward synthesis of 2,4,6-trisubstituted 1,3,5-triazine compounds targeting cysteine cathepsins K and S. Eur J Med Chem121:12-20 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin B
Name:Cathepsin B
Synonyms:APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:Enzyme
Mol. Mass.:37819.69
Organism:Homo sapiens (Human)
Description:gi_63102437
Residue:339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50197886
n/a
NameBDBM50197886
Synonyms:CHEMBL3936923
TypeSmall organic molecule
Emp. Form.C16H19N7
Mol. Mass.309.369
SMILESCc1cccc(CNc2nc(nc(n2)N2CCNCC2)C#N)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: