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TargetCathepsin S
LigandBDBM50197928
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1620103 (CHEMBL3862386)
IC50 102±n/a nM
Citation Plebanek, EChevrier, FRoy, VGarenne, TLecaille, FWarszycki, DBojarski, AJLalmanach, GAgrofoglio, LA Straightforward synthesis of 2,4,6-trisubstituted 1,3,5-triazine compounds targeting cysteine cathepsins K and S. Eur J Med Chem121:12-20 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin S
Name:Cathepsin S
Synonyms:CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:Protein
Mol. Mass.:37507.38
Organism:Homo sapiens (Human)
Description:P25774
Residue:331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50197928
n/a
NameBDBM50197928
Synonyms:CHEMBL3945803
TypeSmall organic molecule
Emp. Form.C17H17F3N6
Mol. Mass.362.3523
SMILESFC(F)(F)c1ccc(Nc2nc(NC3CCCCC3)nc(n2)C#N)cc1
Structure
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