| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 10 |
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| Ligand | BDBM50199055 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1621016 (CHEMBL3863299) |
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| IC50 | 398±n/a nM |
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| Citation |  Abeywardane, A; Caviness, G; Choi, Y; Cogan, D; Gao, A; Goldberg, D; Heim-Riether, A; Jeanfavre, D; Klein, E; Kowalski, JA; Mao, W; Miller, C; Moss, N; Ramsden, P; Raymond, E; Skow, D; Smith-Keenan, L; Snow, RJ; Wu, F; Wu, JP; Yu, Y N-Arylsulfonyl-a-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett26:5277-5283 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 10 |
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| Name: | C-C chemokine receptor type 10 |
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| Synonyms: | C-C CKR-10 | C-C chemokine receptor type 10 | CC-CKR-10 | CCR-10 | CCR10 | CCR10_HUMAN | G-protein coupled receptor 2 | GPR2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38433.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105617 |
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| Residue: | 362 |
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| Sequence: | MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNG
LVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLY
SASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFS
QDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGP
ERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLAL
ARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSW
DN
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| BDBM50199055 |
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| n/a |
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| Name | BDBM50199055 |
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| Synonyms: | CHEMBL3946799 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22Cl2F3N5O3S |
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| Mol. Mass. | 552.397 |
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| SMILES | Nc1c(Cl)cc(cc1Cl)S(=O)(=O)NC(CCn1cccc1C#N)C(=O)N1CCC(CC1)C(F)(F)F |
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| Structure | 
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