Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase BTK |
---|
Ligand | BDBM50161162 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1621769 (CHEMBL3864052) |
---|
IC50 | 0.600000±n/a nM |
---|
Citation | Ge, Y; Jin, Y; Wang, C; Zhang, J; Tang, Z; Peng, J; Liu, K; Li, Y; Zhou, Y; Ma, X Discovery of Novel Bruton's Tyrosine Kinase (BTK) Inhibitors Bearing a ACS Med Chem Lett7:1050-1055 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase BTK |
---|
Name: | Tyrosine-protein kinase BTK |
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
Type: | Enzyme |
Mol. Mass.: | 76289.95 |
Organism: | Homo sapiens (Human) |
Description: | Q06187 |
Residue: | 659 |
Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
|
|
|
BDBM50161162 |
---|
n/a |
---|
Name | BDBM50161162 |
Synonyms: | AVL-292 | CC-292 | Spebrutinib | US10596172, Compound I-182 | US10828300, Compound I-182 | US11351168, Compound I-182 | US9987276, Compound I-182 |
Type | Small organic molecule |
Emp. Form. | C22H22FN5O3 |
Mol. Mass. | 423.4402 |
SMILES | COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)cc1 |
Structure |
|