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TargetCaspase-5
LigandBDBM50200545
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1622627 (CHEMBL3864979)
Ki 34±n/a nM
Citation Kent, CRBryja, MGustafson, HAKawarski, MYLenti, GPierce, ENKnopp, RCCeja, VPati, BWalters, DEKarver, CE Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases. Bioorg Med Chem Lett26:5476-5480 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Caspase-5
Name:Caspase-5
Synonyms:CASP-5 | CASP5 | CASP5_HUMAN | Caspase 5 | Caspase-5 subunit p10 | Caspase-5 subunit p20 | ICE(rel)-III | ICH-3 protease | ICH3 | Protease ICH-3 | Protease TY | TY protease
Type:Enzyme
Mol. Mass.:49760.80
Organism:Homo sapiens (Human)
Description:P51878
Residue:434
Sequence:
MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK
KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR
KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD
EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD
MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC
LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF
CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE
RATLTRDFYLFPGN
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BDBM50200545
n/a
NameBDBM50200545
Synonyms:CHEMBL3965572
TypeSmall organic molecule
Emp. Form.C22H31N7
Mol. Mass.393.5284
SMILESC(N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1)c1ccncc1
Structure
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