Reaction Details |
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Target | Caspase-4 |
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Ligand | BDBM50200548 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1622626 (CHEMBL3864978) |
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Ki | 870±n/a nM |
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Citation | Kent, CR; Bryja, M; Gustafson, HA; Kawarski, MY; Lenti, G; Pierce, EN; Knopp, RC; Ceja, V; Pati, B; Walters, DE; Karver, CE Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases. Bioorg Med Chem Lett26:5476-5480 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Caspase-4 |
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Name: | Caspase-4 |
Synonyms: | CASP-4 | CASP4 | CASP4_HUMAN | Caspase 4 | Caspase-4 subunit 1 | Caspase-4 subunit 2 | ICE(rel)-II | ICH-2 protease | ICH2 | TX protease |
Type: | Enzyme |
Mol. Mass.: | 43257.75 |
Organism: | Homo sapiens (Human) |
Description: | P49662 |
Residue: | 377 |
Sequence: | MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS
MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE
RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT
ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN
RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF
IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP
TIERLSMTRYFYLFPGN
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BDBM50200548 |
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n/a |
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Name | BDBM50200548 |
Synonyms: | CHEMBL3895496 |
Type | Small organic molecule |
Emp. Form. | C22H31N7 |
Mol. Mass. | 393.5284 |
SMILES | C(N1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1)c1cccnc1 |
Structure |
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