| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-4 |
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| Ligand | BDBM50200550 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1622626 (CHEMBL3864978) |
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| Ki | 207±n/a nM |
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| Citation |  Kent, CR; Bryja, M; Gustafson, HA; Kawarski, MY; Lenti, G; Pierce, EN; Knopp, RC; Ceja, V; Pati, B; Walters, DE; Karver, CE Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases. Bioorg Med Chem Lett26:5476-5480 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-4 |
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| Name: | Caspase-4 |
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| Synonyms: | CASP-4 | CASP4 | CASP4_HUMAN | Caspase 4 | Caspase-4 subunit 1 | Caspase-4 subunit 2 | ICE(rel)-II | ICH-2 protease | ICH2 | TX protease |
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| Type: | Enzyme |
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| Mol. Mass.: | 43257.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49662 |
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| Residue: | 377 |
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| Sequence: | MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS
MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE
RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT
ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN
RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF
IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP
TIERLSMTRYFYLFPGN
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| BDBM50200550 |
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| n/a |
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| Name | BDBM50200550 |
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| Synonyms: | CHEMBL3905486 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H26N6 |
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| Mol. Mass. | 302.4178 |
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| SMILES | C1CCN(C1)c1cc(nc(n1)N1CCCC1)N1CCNCC1 |
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| Structure | 
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