| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calmodulin-domain protein kinase 1 |
|---|
| Ligand | BDBM50446179 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1622696 (CHEMBL3865048) |
|---|
| IC50 | 2.0±n/a nM |
|---|
| Citation |  Huang, W; Hulverson, MA; Zhang, Z; Choi, R; Hart, KJ; Kennedy, M; Vidadala, RSR; Maly, DJ; Van Voorhis, WC; Lindner, SE; Fan, E; Ojo, KK 5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents. Bioorg Med Chem Lett26:5487-5491 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calmodulin-domain protein kinase 1 |
|---|
| Name: | Calmodulin-domain protein kinase 1 |
|---|
| Synonyms: | Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 57248.42 |
|---|
| Organism: | Toxoplasma gondii |
|---|
| Description: | n/a |
|---|
| Residue: | 507 |
|---|
| Sequence: | MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN
|
|
|
|---|
| BDBM50446179 |
|---|
| n/a |
|---|
| Name | BDBM50446179 |
|---|
| Synonyms: | CHEMBL3109011 | US9518026, Example 39 | US9956214, Compound 1517 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23N5O2 |
|---|
| Mol. Mass. | 353.4182 |
|---|
| SMILES | CCOc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
