Reaction Details |
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Target | Procathepsin L |
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Ligand | BDBM50201212 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1623051 (CHEMBL3865403) |
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Ki | 20±n/a nM |
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Citation | Latorre, A; Schirmeister, T; Kesselring, J; Jung, S; Johé, P; Hellmich, UA; Heilos, A; Engels, B; Krauth-Siegel, RL; Dirdjaja, N; Bou-Iserte, L; Rodríguez, S; González, FV Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain. ACS Med Chem Lett7:1073-1076 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Procathepsin L |
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Name: | Procathepsin L |
Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
Type: | Enzyme |
Mol. Mass.: | 37557.19 |
Organism: | Homo sapiens (Human) |
Description: | Purchased from Calbiochem (San Diego, CA). |
Residue: | 333 |
Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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BDBM50201212 |
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n/a |
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Name | BDBM50201212 |
Synonyms: | CHEMBL3974129 |
Type | Small organic molecule |
Emp. Form. | C28H29N3O5 |
Mol. Mass. | 487.547 |
SMILES | [O-][N+](=O)\C=C\[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r| |
Structure |
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