| Reaction Details |
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 | Report a problem with these data |
| Target | N-lysine methyltransferase KMT5A |
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| Ligand | BDBM50201571 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1623119 (CHEMBL3865471) |
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| IC50 | 330±n/a nM |
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| Citation |  Judge, RA; Zhu, H; Upadhyay, AK; Bodelle, PM; Hutchins, CW; Torrent, M; Marin, VL; Yu, W; Vedadi, M; Li, F; Brown, PJ; Pappano, WN; Sun, C; Petros, AM Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8. ACS Med Chem Lett7:1102-1106 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-lysine methyltransferase KMT5A |
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| Name: | N-lysine methyltransferase KMT5A |
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| Synonyms: | KMT5A | KMT5A_HUMAN | N-lysine methyltransferase SETD8 | PRSET7 | SET domain-containing protein 8 (SetD8) | SET07 | SET8 | SETD8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42919.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NQR1 |
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| Residue: | 393 |
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| Sequence: | MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAA
AAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHH
EVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPK
TPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQ
SEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKRE
ALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLI
LIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
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| BDBM50201571 |
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| n/a |
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| Name | BDBM50201571 |
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| Synonyms: | CHEMBL3934996 |
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| Type | Small organic molecule |
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| Emp. Form. | C49H90N20O10 |
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| Mol. Mass. | 1119.3669 |
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| SMILES | CCCCC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r| |
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| Structure | 
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