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TargetSET domain-containing protein 8 (SetD8)
LigandBDBM50051116
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1623122
Ki 2000±n/a nM
Citation Judge RAZhu HUpadhyay AKBodelle PMHutchins CWTorrent MMarin VLYu WVedadi MLi FBrown PJPappano WNSun CPetros AM Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8. ACS Med Chem Lett 7:1102-1106 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
SET domain-containing protein 8 (SetD8)
Name:SET domain-containing protein 8 (SetD8)
Synonyms:N-lysine methyltransferase SETD8
Type:Enzyme
Mol. Mass.:42919.11
Organism:Homo sapiens (Human)
Description:Q9NQR1
Residue:393
Sequence:
MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAA
AAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHH
EVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPK
TPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQ
SEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKRE
ALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLI
LIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50051116
n/a
NameBDBM50051116
Synonyms:CHEMBL3318284
TypeSmall organic molecule
Emp. Form.C30H50O7
Mol. Mass.522.7138
SMILES[H][C@]12[C@@H](C)[C@H](O)C[C@@H](O)[C@@]1(C)C=C(C)[C@H]([C@@H]2\C=C(/C)C(O)=O)C(C)=CC[C@H](O)C[C@@H](O)[C@H](C)[C@@H](O)C(C)C |r,t:12|
Structure
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