| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C theta type |
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| Ligand | BDBM50201641 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1623198 (CHEMBL3865550) |
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| IC50 | 7.0±n/a nM |
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| Citation |  McCoull, W; Hennessy, EJ; Blades, K; Chuaqui, C; Dowling, JE; Ferguson, AD; Goldberg, FW; Howe, N; Jones, CR; Kemmitt, PD; Lamont, G; Varnes, JG; Ward, RA; Yang, B Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors. ACS Med Chem Lett7:1118-1123 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C theta type |
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| Name: | Protein kinase C theta type |
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| Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 81878.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length human PKC theta (Panvera Catalog No. P2996). |
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| Residue: | 706 |
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| Sequence: | MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF
DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR
YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV
WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK
SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ
ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP
EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD
DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR
ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC
GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR
WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD
CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
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| BDBM50201641 |
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| n/a |
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| Name | BDBM50201641 |
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| Synonyms: | CHEMBL3923175 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H36FN7O3S |
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| Mol. Mass. | 629.747 |
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| SMILES | CCS(=O)(=O)c1cc(Nc2ncc(F)c(n2)N(Cc2ccccc2C#N)c2cc(CO)ccc2C)ccc1N1CCN(C)CC1 |
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| Structure | 
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