Reaction Details |
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Target | Tyrosine-protein kinase BTK |
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Ligand | BDBM50201719 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1623333 (CHEMBL3865685) |
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IC50 | 43±n/a nM |
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Citation | Pujala, B; Agarwal, AK; Middya, S; Banerjee, M; Surya, A; Nayak, AK; Gupta, A; Khare, S; Guguloth, R; Randive, NA; Shinde, BU; Thakur, A; Patel, DI; Raja, M; Green, MJ; Alfaro, J; Avila, P; Pérez de Arce, F; Almirez, RG; Kanno, S; Bernales, S; Hung, DT; Chakravarty, S; McCullagh, E; Quinn, KP; Rai, R; Pham, SM Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kd. ACS Med Chem Lett7:1161-1166 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase BTK |
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Name: | Tyrosine-protein kinase BTK |
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
Type: | Enzyme |
Mol. Mass.: | 76289.95 |
Organism: | Homo sapiens (Human) |
Description: | Q06187 |
Residue: | 659 |
Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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BDBM50201719 |
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n/a |
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Name | BDBM50201719 |
Synonyms: | CHEMBL3957821 |
Type | Small organic molecule |
Emp. Form. | C21H19N5O |
Mol. Mass. | 357.4085 |
SMILES | Cc1ccc(cc1O)-c1nn(C2Cc3ccccc3C2)c2ncnc(N)c12 |
Structure |
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