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TargetArachidonate 5-lipoxygenase-activating protein
LigandBDBM50202472
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1624267 (CHEMBL3866679)
IC50 170±n/a nM
Citation Levent, SGerstmeier, JOlgaç, ANikels, FGarscha, UCarotti, AMacchiarulo, AWerz, OBanoglu, EÇaliskan, B Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7. Eur J Med Chem122:510-519 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Arachidonate 5-lipoxygenase-activating protein
Name:Arachidonate 5-lipoxygenase-activating protein
Synonyms:5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:Enzyme
Mol. Mass.:18159.90
Organism:Homo sapiens (Human)
Description:P20292
Residue:161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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BDBM50202472
n/a
NameBDBM50202472
Synonyms:CHEMBL3927809
TypeSmall organic molecule
Emp. Form.C30H31F3N2O
Mol. Mass.492.5751
SMILESCC(C)Cc1ccc(cc1)C(C)c1nc2cc(OCC=C)ccc2n1Cc1ccccc1C(F)(F)F
Structure
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