| Reaction Details |
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 | Report a problem with these data |
| Target | Arachidonate 5-lipoxygenase-activating protein |
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| Ligand | BDBM50202476 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1624267 (CHEMBL3866679) |
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| IC50 | 210±n/a nM |
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| Citation |  Levent, S; Gerstmeier, J; Olgaç, A; Nikels, F; Garscha, U; Carotti, A; Macchiarulo, A; Werz, O; Banoglu, E; Çaliskan, B Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7. Eur J Med Chem122:510-519 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Arachidonate 5-lipoxygenase-activating protein |
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| Name: | Arachidonate 5-lipoxygenase-activating protein |
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| Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein |
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| Type: | Enzyme |
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| Mol. Mass.: | 18159.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P20292 |
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| Residue: | 161 |
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| Sequence: | MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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| BDBM50202476 |
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| n/a |
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| Name | BDBM50202476 |
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| Synonyms: | CHEMBL3945688 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31F3N2O3 |
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| Mol. Mass. | 524.5739 |
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| SMILES | COC(=O)COc1ccc2n(Cc3ccccc3C(F)(F)F)c(nc2c1)C(C)c1ccc(CC(C)C)cc1 |
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| Structure | 
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