| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H1 receptor |
|---|
| Ligand | BDBM50202833 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1624854 (CHEMBL3867266) |
|---|
| Ki | 7.9±n/a nM |
|---|
| Citation |  Kuhne, S; Kooistra, AJ; Bosma, R; Bortolato, A; Wijtmans, M; Vischer, HF; Mason, JS; de Graaf, C; de Esch, IJ; Leurs, R Identification of Ligand Binding Hot Spots of the Histamine H J Med Chem59:9047-9061 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H1 receptor |
|---|
| Name: | Histamine H1 receptor |
|---|
| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 55808.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
|---|
| Residue: | 487 |
|---|
| Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
|
|
|
|---|
| BDBM50202833 |
|---|
| n/a |
|---|
| Name | BDBM50202833 |
|---|
| Synonyms: | CHEMBL3984221 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27NO5 |
|---|
| Mol. Mass. | 397.4642 |
|---|
| SMILES | OC(=O)\C=C\C(O)=O.C(COc1ccccc1Cc1ccccc1)CN1CCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
