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TargetAlpha-1A adrenergic receptor
LigandBDBM50201789
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1625178
Ki 2.8±n/a nM
Citation Silva ROde Oliveira ASNunes Lemes LFde Camargo Nascente LCoelho do Nascimento Nogueira PSilveira ERBrand GDVistoli GCilia APoggesi EBuccioni MMarucci GBolognesi MLRomeiro LAS Synthesis and structure-activity relationships of novel arylpiperazines as potent antagonists ofa1-adrenoceptor. Eur J Med Chem 122:601-610 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alpha-1A adrenergic receptor
Name:Alpha-1A adrenergic receptor
Synonyms:ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:Cell-surface receptors
Mol. Mass.:51511.67
Organism:Homo sapiens (Human)
Description:P35348
Residue:466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
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  Blast E-value cutoff:
BDBM50201789
n/a
NameBDBM50201789
Synonyms:CHEMBL3946843
TypeSmall organic molecule
Emp. Form.C22H30N2O2
Mol. Mass.354.4858
SMILESCOc1cccc(CCN2CCN(CC2)c2ccccc2OC(C)C)c1
Structure
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