| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1A adrenergic receptor |
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| Ligand | BDBM50201789 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1625178 (CHEMBL3867647) |
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| Ki | 2.8±n/a nM |
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| Citation |  Silva, RO; de Oliveira, AS; Nunes Lemes, LF; de Camargo Nascente, L; Coelho do Nascimento Nogueira, P; Silveira, ER; Brand, GD; Vistoli, G; Cilia, A; Poggesi, E; Buccioni, M; Marucci, G; Bolognesi, ML; Romeiro, LAS Synthesis and structure-activity relationships of novel arylpiperazines as potent antagonists ofa1-adrenoceptor. Eur J Med Chem122:601-610 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1A adrenergic receptor |
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| Name: | Alpha-1A adrenergic receptor |
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| Synonyms: | ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C |
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| Type: | Cell-surface receptors |
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| Mol. Mass.: | 51511.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35348 |
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| Residue: | 466 |
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| Sequence: | MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
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| BDBM50201789 |
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| n/a |
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| Name | BDBM50201789 |
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| Synonyms: | CHEMBL3946843 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H30N2O2 |
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| Mol. Mass. | 354.4858 |
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| SMILES | COc1cccc(CCN2CCN(CC2)c2ccccc2OC(C)C)c1 |
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| Structure | 
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