| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid 21-hydroxylase |
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| Ligand | BDBM50203340 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1625605 (CHEMBL3868074) |
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| IC50 | 49±n/a nM |
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| Citation |  Blass, BE; Iyer, P; Abou-Gharbia, M; Childers, WE; Gordon, JC; Ramanjulu, M; Morton, G; Arumugam, P; Boruwa, J; Ellingboe, J; Mitra, S; Nimmareddy, RR; Paliwal, S; Rajasekhar, J; Shivakumar, S; Srivastava, P; Tangirala, RS; Venkataramanaiah, K; Yanamandra, M Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome. Bioorg Med Chem Lett26:5825-5829 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Steroid 21-hydroxylase |
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| Name: | Steroid 21-hydroxylase |
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| Synonyms: | CP21A_HUMAN | CYP21 | CYP21A2 | CYP21B | Cytochrome P450 21 | Cytochrome P450 21A2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55896.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1498865 |
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| Residue: | 494 |
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| Sequence: | MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYR
LHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAHK
KLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDK
IKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQ
LRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTL
SWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVP
LALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALA
FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRL
QPRGMGAHSPGQNQ
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| BDBM50203340 |
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| n/a |
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| Name | BDBM50203340 |
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| Synonyms: | CHEMBL3938615 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25Cl2F3N4O5S |
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| Mol. Mass. | 621.456 |
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| SMILES | FC(F)(F)S(=O)(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1 |r| |
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| Structure | 
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