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TargetOrexin receptor type 2
LigandBDBM50203733
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1625870 (CHEMBL3868339)
Ki>4379±n/a nM
Citation Stump, CACooke, AJBruno, JCabalu, TDGotter, ALHarell, CMKuduk, SDMcDonald, TPO'Brien, JRenger, JJWilliams, PDWinrow, CJColeman, PJ Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology. Bioorg Med Chem Lett26:5809-5814 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Orexin receptor type 2
Name:Orexin receptor type 2
Synonyms:HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:Protein
Mol. Mass.:50710.53
Organism:Homo sapiens (Human)
Description:O43614
Residue:444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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  Blast E-value cutoff:
BDBM50203733
n/a
NameBDBM50203733
Synonyms:CHEMBL3979157
TypeSmall organic molecule
Emp. Form.C21H17F3N2O2
Mol. Mass.386.3671
SMILESFc1ccc(cc1)C(=O)N1CCC(F)(F)C(C1)Oc1ccc2ccccc2n1
Structure
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