| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Orexin receptor type 2 |
|---|
| Ligand | BDBM50203762 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1625870 (CHEMBL3868339) |
|---|
| Ki | >3370±n/a nM |
|---|
| Citation |  Stump, CA; Cooke, AJ; Bruno, J; Cabalu, TD; Gotter, AL; Harell, CM; Kuduk, SD; McDonald, TP; O'Brien, J; Renger, JJ; Williams, PD; Winrow, CJ; Coleman, PJ Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology. Bioorg Med Chem Lett26:5809-5814 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Orexin receptor type 2 |
|---|
| Name: | Orexin receptor type 2 |
|---|
| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 50710.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O43614 |
|---|
| Residue: | 444 |
|---|
| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
|
|
|
|---|
| BDBM50203762 |
|---|
| n/a |
|---|
| Name | BDBM50203762 |
|---|
| Synonyms: | CHEMBL3955784 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H14F2N4O2 |
|---|
| Mol. Mass. | 308.2834 |
|---|
| SMILES | OC1CN(CCC1(F)F)C(=O)c1ccccc1-n1nccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
