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TargetStromelysin-2
LigandBDBM50203953
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1625935 (CHEMBL3868404)
IC50 0.300000±n/a nM
Citation Nara, HSato, KKaieda, AOki, HKuno, HSantou, TKanzaki, NTerauchi, JUchikawa, OKori, M Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors. Bioorg Med Chem24:6149-6165 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Stromelysin-2
Name:Stromelysin-2
Synonyms:MMP10 | MMP10_HUMAN | Matrix Metalloproteinase-10 (MMP-10) | Matrix metalloproteinase 10 | STMY2
Type:Enzyme
Mol. Mass.:54143.02
Organism:Homo sapiens (Human)
Description:P09238
Residue:476
Sequence:
MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV
KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY
TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL
AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN
SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST
LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW
AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG
FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
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  Blast E-value cutoff:
BDBM50203953
n/a
NameBDBM50203953
Synonyms:CHEMBL3932562
TypeSmall organic molecule
Emp. Form.C27H27N5O6S
Mol. Mass.549.598
SMILESCC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1)C(=O)NO |r|
Structure
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