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TargetNeutrophil collagenase
LigandBDBM50203960
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1625933 (CHEMBL3868402)
IC50 32±n/a nM
Citation Nara, HSato, KKaieda, AOki, HKuno, HSantou, TKanzaki, NTerauchi, JUchikawa, OKori, M Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors. Bioorg Med Chem24:6149-6165 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neutrophil collagenase
Name:Neutrophil collagenase
Synonyms:CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:Enzyme
Mol. Mass.:53413.48
Organism:Homo sapiens (Human)
Description:P22894
Residue:467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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  Blast E-value cutoff:
BDBM50203960
n/a
NameBDBM50203960
Synonyms:CHEMBL3892938
TypeSmall organic molecule
Emp. Form.C23H23N9O3
Mol. Mass.473.4872
SMILESO=C(Cc1nnn[nH]1)N1CCN(CC1)c1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1
Structure
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