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TargetMatrilysin
LigandBDBM50203961
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1625932 (CHEMBL3868401)
IC50 2000±n/a nM
Citation Nara, HSato, KKaieda, AOki, HKuno, HSantou, TKanzaki, NTerauchi, JUchikawa, OKori, M Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors. Bioorg Med Chem24:6149-6165 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Matrilysin
Name:Matrilysin
Synonyms:MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:Enzyme
Mol. Mass.:29681.54
Organism:Homo sapiens (Human)
Description:P09237
Residue:267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLK
EMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDL
PHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAF
APGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGD
PQNFKLSQDDIKGIQKLYGKRSNSRKK
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  Blast E-value cutoff:
BDBM50203961
n/a
NameBDBM50203961
Synonyms:CHEMBL3958969
TypeSmall organic molecule
Emp. Form.C25H29N5O7S
Mol. Mass.543.592
SMILESONC(=O)C1CCCCN1S(=O)(=O)CCCOc1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1
Structure
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