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TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha
LigandBDBM50204072
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1626045 (CHEMBL3868514)
Ki 12±n/a nM
Citation Kick, EKBusch, BBMartin, RStevens, WCBollu, VXie, YBoren, BCNyman, MCNanao, MHNguyen, LPlonowski, ASchulman, IGYan, GZhang, HHou, XValente, MNNarayanan, RBehnia, KRodrigues, ADBrock, BSmalley, JCantor, GHLupisella, JSleph, PGrimm, DOstrowski, JWexler, RRKirchgessner, TMohan, R Discovery of Highly Potent Liver X Receptorß Agonists. ACS Med Chem Lett7:1207-1212 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Oxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha
Name:Oxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha
Synonyms:Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-beta
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 2032722
Components:This complex has 2 components.
Component 1
Name:Retinoic acid receptor RXR-alpha
Synonyms:NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:PROTEIN
Mol. Mass.:50820.38
Organism:Homo sapiens (Human)
Description:ChEMBL_1456363
Residue:462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
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Component 2
Name:Oxysterols receptor LXR-beta
Synonyms:LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:50978.79
Organism:Homo sapiens (Human)
Description:P55055
Residue:460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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BDBM50204072
n/a
NameBDBM50204072
Synonyms:CHEMBL3945199 | US10543183, Compound 12 | US10945978, Compound 12
TypeSmall organic molecule
Emp. Form.C29H28Cl2F2N2O4S
Mol. Mass.609.511
SMILESCC(C)(O)c1cn(c(n1)C(C)(C)c1c(Cl)cccc1Cl)-c1ccc(cc1F)-c1cc(F)c(CO)c(c1)S(C)(=O)=O
Structure
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